Well, I think I’m going to get myself one of these; I’m going to work on the theory that the more tests I can put myself through, the more assessments I have, the more consultants I see, the more research I can do, the more knowledgeable I shall become about Bipolar. Knowledge is Power said Socrates and increased knowledge may bring about some much-needed questioning of how Bipolar is diagnosed and therefore the validity of such diagnoses in their application to determining someone’s parenting or employment ability…..

Bipolar case stirs debate about at-home genetics testing
The Associated Press Published Tuesday, March 25, 2008

http://www.newsminer.com/news/2008/mar/25/bipolar-case-stirs-debate-about–home-genetics-tes/

SAN DIEGO — Dr. John Kelsoe has spent his career trying to identify the biological roots of bipolar disorder. In December, he announced he had discovered several gene mutations closely tied to the disease, also known as manic depression.

Then Kelsoe, a prominent psychiatric geneticist at the University of California-San Diego, did something provocative for the buttoned-down world of academic medical research: He began selling bipolar genetic tests straight to the public over the Internet last month for $399.

His company, La Jolla-based Psynomics, joins a legion of startups racing to exploit the boom in research connecting genetic variations to a host of health conditions. More than 1,000 at-home gene tests have burst onto the market in the past few years.

The proliferation of these tests troubles many public health officials, medical ethicists and doctors. The tests receive almost no government oversight, even though many of them are being sold as tools for making serious medical decisions.

Health experts worry that many of these products are built on thin data and are preying on individuals’ deepest anxieties.

“People are always rushing to the market on the basis of one or two studies,” said Dr. Muin Khoury, director of the National Office of Public Health Genomics at the Centers for Disease Control and Prevention. “We have very little evidence that telling people their genetic information is going to make any difference.”

Tests have become available claiming to help predict and diagnose everything from serious illnesses like cancer and Alzheimer’s to athletic ability and a person’s ideal diet. Psynomics’ offering is one of the first psychiatric gene tests on the market.

Kelsoe, 52, acknowledges that bipolar disorder probably results from a combination of genetic factors and life experiences, and that the presence of these gene variations does not at all mean that someone will, in fact, develop the disease. He admits, too, that his findings about the genetic basis of the illness are far from complete.

But he said his test is a vital starting point toward moving away from the notoriously tricky practice of diagnosing bipolar disorder based purely on a person’s behavior.

“The goal of this is to try and help doctors make an accurate diagnosis more quickly so the patient can be treated appropriately,” Kelsoe said. “Anything is going to help, even if it just helps a little bit.”

Bipolar sufferers experience intense mood swings as they cycle between manic, sometimes delusional highs and depressive lows that can lead to suicide if untreated. The disease is often misdiagnosed as other forms of depression, which delays treatment and can result in the prescribing of antidepressants that make some patients’ symptoms worse.

To take the test, patients receive by mail a plastic cup that they spit into, seal and send back to Psynomics. The company analyzes DNA in the saliva.

Psynomics will send patients’ test results only to their doctors to avoid the risk of self-diagnosis.

The report that accompanies those results instructs doctors that a positive test means patients are two to three times more likely to have bipolar disorder. But the studies from which those figures come also show the gene variations themselves are rare even among those with bipolar.

The report also points out that for now, the test is valid only for whites of Northern European ancestry who show some behavioral symptoms and have at least one other bipolar family member.

Patients taking Psynomics’ bipolar test may feel branded by a positive result, even if they are not ultimately diagnosed with the disorder, said Hank Greely, a professor of law and genetics with the Stanford Center for Biomedical Ethics. Or they may feel false hope from a negative result, despite the company’s disclaimers.

Likewise, doctors have little training beyond what companies tell them when it comes to applying the test results. “They may make a foolish decision that backfires to put you on meds,” Greely said. “Or they may make a decision that backfires not to put you on meds.”

Unlike many tests for other conditions on the market, Psynomics does not claim its bipolar test can predict a person’s risk of developing the disorder later in life. It is meant to be used as a purely diagnostic tool for patients already showing symptoms.

That is an important distinction that makes the Psynomics test more responsible than others that promise a glimpse into the genetic crystal ball, according to Dr. Greg Feero, head of genomic health care at the National Human Genome Research Institute.

“Now you’re talking about an individual who has symptoms or signs that already put them in a very different risk category than someone who has no symptoms or signs,” Feero said.

Among hundreds of families Kelsoe has studied, one of the gene variations in the Psynomics test showed up in 1 percent of those unaffected by the disorder versus 3 percent who are affected. The other variation appeared in 7 percent of those without bipolar compared to 15 percent who have the disease.

Many other genes interacting with a patient’s environment contribute to the development of bipolar disorder, Kelsoe and other researchers believe, meaning no single genetic variation ultimately causes the disease. Researchers in Kelsoe’s lab are working to track down more genes.

“Why are we starting before it’s finished? You’ve got to start somewhere,” Kelsoe said. “Even if we knew everything about the genes, which we certainly don’t, it’s never going to be 100 percent predictive.”

Psynomics has sold only a few tests so far but is projecting sales of 1,800 tests in 2008 and 30,000 in the next five years.

In coming months, at least two other startups led by genetic researchers are set to release their own psychiatric genetic tests. One test claims to predict the risk of developing schizophrenia. The other is designed to forecast the likelihood that some medications for major depression could heighten suicidal thoughts in patients.

The American Psychiatric Association has yet to create an official policy on genetic testing. A fact sheet issued by the Federal Trade Commission advises consumers to be wary of assertions made by at-home genetic testing companies.

The Food and Drug Administration does not evaluate the tests for accuracy, though a panel is working on a set of standards for the growing industry.

For now, worry persists that with the proliferation of tests, there is too little understanding of what to do with the results, or what they mean.

“We just don’t know how people will use the information,” said Dr. Jinger Hoop, a professor of psychiatric genetics and medical ethics at the Medical College of Wisconsin in Milwaukee. “We don’t know whether it will be helpful to them in the long run.”

I just came across this piece which is a letter written to the Financial times. Makes for interesting reading given that people who are suffering with an unpleasant and unpredictable boss put it down to a variety of causes including Bipolar, drugs, personality, environment, culture etc. Great to read all the different perceptions….

http://blogs.ft.com/dearlucy/2007/07/i-think-my-bosshtml/

‘I think my boss may be bipolar’
July 10, 2007
I think my boss may be bipolar. He has two different modies: he’s either charging round, full of energy, making bold decisions or he’s paranoid, negative and bullying. In the “up” moods he’s stimulating, though it’s exhausting trying to keep up. The rest of the time he is paranoid and hostile. I’ve worked for him for two years and though I admire his talent and charisma I find his mood swings increasingly stressful. A couple of weeks ago I tried to broach the matter, but he looked as if he was about to have a coronary, so I shut up. Is there anything I can do? And if not, how can I insulate myself from the worst of his rages?

Investment banker, male, 36

July 10th, 2007 in Uncategorised | Permalink

19 Responses to “‘I think my boss may be bipolar’”
Comments
They say people join companies and leave managers – it is quite true. I am a victim of a similar situation, and the only way I have managed to survive is by telling myself that you cannot change a person – especially your boss – you can only change your reaction to him. Try being objective, impersonal, and to-the-point. Maintain a steady unfluctuating disposition, that should lessen the blow of the mood swings. But if despite all this you feel you cant be happy working this way, the world is big and it is full of opportunities

Posted by: Anonymous | July 10th, 2007 at 2:53 pm | Report this comment

I had a boss who was very similar – she ended up driving me into depression. The situation may not get any better and this can have an impact on you.

The lack of rationality that you have to cope with can put enough mental pressure on you that it causes you to question your judgement and eventually you follow the mood swings.

That’s good for no-one.

It’s also worth condsidering your boss may have a drugs problem, this can have similar effects to mental illness.

Posted by: Aaron | July 10th, 2007 at 4:34 pm | Report this comment

If your boss is really bipolar then he will exhibit those two different modes when dealing with senior colleagues and potential clients, as well as when dealing with a junior colleague. It doesn’t seem very likely that he would have lasted even two years in his job if he were paranoid and hostile with clients and his boss. It is perhaps more likely that he suffers from “kicking the dog” syndrome, bouts of which could be triggered by business disappointments. You are working in a deal driven organisation. Every mandate won or lost, every issue floated or pulled and every time that market prices do or don’t perform near expectations affect reputations, remuneration and prospects. Every potential deal is a one-off opportunity from which to wring every penny of fees and every nuance of status and ranking. It is not an environment where anyone is likely to appreciate a good loser so either be just as bad a loser as your boss or try to move to a longer term client relationship position.

Posted by: Ironybrew, 57, Retired, Male | July 10th, 2007 at 5:15 pm | Report this comment

Insight meditation is the answer. I used to have an extremely nasty boss – the owner of a small company who would appear charming and charismatic to potential clients, yet would treat his employees with total contempt.

Insight meditation (vipassana meditation) is a practice that literally changes the way your brain functions so as you are no longer hurt or upset by the actions of others. The practice takes a couple of months until you see a clear benefit, but trust me, it really works.

Not only are you better able to deal with difficult people, you will also increase your concentration by a huge amount and therefore perform better at work, and enjoy your life more overall.

You will find over the course of a few months that everyday life becomes increasingly pleasurable as you become more open to experience and less reactive to changing moods.

The power it gives you to sit calmly smiling whilst some ego-maniac shouts at you, and see them unable to understand why you are totally unaffected by them is reason enough to do it, but actually, the greater strength will come from not even needing to.

Posted by: Anonymous | July 11th, 2007 at 10:00 am | Report this comment

I’m in a similar position, and I find that the manager’s moods are affecting me in a very negative way. In fact, his behavior is making me depressed and that is spilling over into my family life. My family and friends are highly aware of the change in me, as well as the cause, and they have urged me to quit the job in order to be away from this negative influence. I’m in the process of doing that right now, as there is no way to change that person or to tolerate his abusive persona much longer.

Posted by: Fed Up | July 11th, 2007 at 3:51 pm | Report this comment

It’s not your responsibility to change your boss, except in the sense of finding a new one! Let the market decide the fate of dysfunctional supervisors…

Posted by: Vince Woodward | July 11th, 2007 at 6:32 pm | Report this comment

Sounds like a coke problem to me. Bipolar people aren’t paranoid and bullying in their down phases – they’re usually apathetic and totally non-functional. Take comfort by confiding in your colleagues – you can gain strength by having a laugh behind his back. Also be secure in the knowledge that in a couple more years he’ll crash and burn in a blaze of septum-ruptured glory – leaving you, the survivor, to the spoils.

Posted by: Female, PR, 25 | July 12th, 2007 at 8:19 am | Report this comment

Do we have the same boss? My tuppence worth from the City trenches: try to keep out of his way, try only to report success and watch the sits-vac ads.

Posted by: Craigoh | July 12th, 2007 at 12:36 pm | Report this comment

I have also been in this situation – only afterwards did we realise it was cocaine abuse.

I gave away so much of my internal energy to a complete idiot – never again. I would now instantly switch off and cease to care if someone attempted to treat me like that.

Try alerting whoever is ultimately in charge to what is going on and that it may be drug-related.

Posted by: Lulu | July 12th, 2007 at 1:11 pm | Report this comment

Worse if the boss is a woman. There are so many dysfunctional people in the City these days, that it is almost impossible to find the normal ones among us.

The best remedy is to find a new job and leave that “boss” to rot in his own mess…unless of course, you are a certified psychiatrist.

Posted by: Connie | July 12th, 2007 at 1:51 pm | Report this comment

In my experience you may wish to consider notifying HR or go to Occupational Health. Don’t sit back and do nothing

This is more and more common in the city. Drugs and stress play a part in many cases.

Your boss may want to consider an assesment at Life Works , a treatment facility in Duke Street that runs an Intensive Evening Program for Impaired Professionals. I know Professionals who have had their lives turned around by this course.

Life Works is now regarded as the best treatment facility of its kind in the UK for getting high achievers back on the path.

They also have a residential facility in Surrey that is very highly regarded.

Posted by: Marco | July 12th, 2007 at 2:28 pm | Report this comment

It is not just confined to the City. I experienced something similar in the public sector. It wasn’t drugs – my female boss simply had appalling inter-personal skills. Eventually (after I had left, her behaviour being a principle reason) she was moved to a different position where she wasn’t allowed to manage anyone. If you are confident your HR department will respond in an impartial manner, I’d speak to them.

Posted by: Kate | July 12th, 2007 at 4:22 pm | Report this comment

I had a similar situation with two male bosses simultaneously. The most senior of the two was an unfortunate combination of huge ego and massive insecurity; and was a divisive bully. It was so obvious to all members of my team, that our way of handling this was to bond over our derision and simply tolerate him.

The second of the two was my immediate boss and not as conspicuous. He was aggressive, and frequently phoned me out of hours or when I was on holiday to shout abuse at me because something hadn’t gone to plan, or he’d made a mistake and was seeking to pass blame. Just as my confidence was hitting rock bottom and I was thinking about quitting, I was headhunted and snapped up a much better offer at a better company. In my exit interview, I gave HR a no-holds-barred account of their behaviour. Shortly after I left, I bumped into my ex-immediate boss at a social event. He told me he was in AA and apologised for his treatment of me.

I agree with the comments already posted; it sounds as if your boss has a problem with substance abuse, or at least needs to seek help for a mental health issue. Speak to HR and keep your eye on the job market. Life is too short to tread on eggshells because of your boss’s inability to address his personal problems.

Posted by: Emma | July 12th, 2007 at 5:26 pm | Report this comment

I am battling the same issue. My boss is at least open minded enough that I have discussed the problem with her – which helped.
She blames the mood swings on a physical illness she suffers with, I am sure that is true to an extent but is not a full explanation.
I manage the problem by: (1) just accepting that her poor interpersonal skills mean mean she will never really understand why her unpredictable moods are a problem for us; and (2) in my head she lives in a ‘box’ and I only allow her out of that box in office hours – this has stopped me stressing about her out of office hours so makes the problem manageable. Interestingly this method was given to me by her boss who faces the same problem with her!
John, Banker

Posted by: John | July 14th, 2007 at 1:20 pm | Report this comment

I had a boss like this once. We observed that on days when he was rushed and grabbed a few donuts and coffee from the catering cart, he was nasty as a bear, but on days when he’d had breakfast at home, he was the kindest, smartest boss one could have. After charting this for a couple of weeks, we asked him if he might perhaps have a blood sugar problem. It turned out that he was diabetic! With diet, exercise and insulin, he’s much more even-keeled most times.

Posted by: Jean Mansen | July 16th, 2007 at 6:24 am | Report this comment

Dear Lucy

My problem concerns a columnist on my daily newspaper. She is really funny and sends everything up very cleverly. But a couple of weeks ago, she started referring to people who behave strangely as “nutters”. I think this is a very unkind and dismissive way to talk about people who struggle courageously with bipolar disorder and/or mental illness. I’m worried that if I tell her what I think, she’ll dismiss me as politically correct or a member of the green ink brigade. I’m worried that she’ll start calling people poofs or darkies next. What should I do?

Yours sincerely

HR Consultant (I know! I know!)
Female 59

Posted by: Sally Phillips | August 3rd, 2007 at 9:16 am | Report this comment

I strongly suggest you leave your boss as quickly as possible. I worked for someone like that, too. The best thing he ever did was tell me that I’d been declared redundant. I left him have never looked back.

Seriously, life is far too short to work for a boss like yours. I’m sure you have enough to worry about and complete every day. The last thing you need is a boss suffering from a neurosis you cannot control — and he won’t either.

Posted by: Doug | August 10th, 2007 at 3:53 pm | Report this comment

This sounds very familiar. I’m in a similar situation, and having always wondered why people got sick leave for “stress” (being a strong-minded individual) I now understand completely as I’m hating my own boss (who sounds like yours) and only staying here till I find something else. However, this might not be the best time to be looking for a job as an investment banker! Good luck – you’ll never change him, though, so unless you can somehow get rid of him you’ll have to put up with it or leave.

Posted by: analyst, female, 32 | August 14th, 2007 at 9:58 am | Report this comment

I just quit a job like yours. My boss has been diagnosed with bipolar disorder for 20+ yrs. I believe he uses his illness as a crutch for saying and doing whatever he feels at the time. He forgets half of what he says, he expects me to find his lost items and makes false accusations consistently. I know he drinks alcohol on occassion and doesn’t always take his meds. He doesn’t hesitate to ask if someone wore their stupid hat that day. One time I thought he was going to hit our receptionist. When he is up, he’s fun and full of spunk, when he’s down, he doesn’t care who’s way he get’s in. I’ve even heard him “yell” at his banker for using the work “closing” rather than the word “refinance”. He utilized my time for “lectures” and got mad when the work didn’t get done. I will never accept another position of this nature. I ended up on Paxil while I was there just to cope, my doctor advised I quit working for this man, which I eventually did.

Do you think it’s ‘bad’ to have
a mental health problem? If the answer’s “no” then why use any of these words?

Abnormal Bananas
Barmy Basketcase
Bonkers Braindamaged
Brain-dead
Cabbage Cracked up
Crank Crazy Cripple
Dangerous Densse
Deranged Dim
Disruptive Disturbed
Div Do-Lally Dumb
Faggot Fierce Flid
Freak Fruitcake Funnyin-
the-head Handicapped
Hard-to-listen-to Hardto-
speak-to Hard-tounderstand
Headcase
Hollow-in-the-head
Insane Lights on but
no-one at home Loony
Lost their marbles
Mad Maniac Mental
Mong Mongrel Mute
Not all there Not right
upstairs Nut Nutcase
Nutter Nutty as a fruitcake
Odd Off-their-head
Off-their-rocker
Off-their-trolley
Out-of-your-head
Psycho Queer
Retard Sad Scary
Screw loose Screwed up
Simple Sick Slow
Social problems Spacka
Spanner Spastic Spas-o
Spoon Strange Stupid
Thick Uncapable
Unbalanced Unloved
Unpredictable
Unssttablle Veggies
Violent Wacko Wacky
Weird Wrong-inthe-
head